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Brigitte Henn(-Prassek) was born in Bruntál in former Czechoslovakia. She began her voice studies in Frankfurt am Main with Emmy Greif, continuing at the Music Academy there under Gertrude Pitzinger before moving to Helena Braun in Wiesbaden. Finally, she was a pupil of the singer and voice teacher Raymond Henn in Basel, whom she married.
From 1968-75 she was employed by Basel Theatre, after which she made frequent guest appearances at Deutsche Oper Berlin (1976-80) before returning to Basel with a guest contract that started in 1982. She made many guest appearances at the state opera houses of Munich and Stuttgart, at Deutsche Oper am Rhein Düsseldorf-Duisburg, at the opera houses of Frankfurt am Main and Zurich, and at Hanover State Theatre.
Highlights in her stage repertoire include the Countess in “The Marriage of Figaro”, Donna Elvira in “Don Giovanni”, Fiordiligi in “Così fan tutte”, Marzelline in “Fidelio”, Agathe in “Der Freischütz”, Euridice in Gluck’s “Orfeo”, Mařenka in Smetana’s “Bartered Bride”, Senta in “The Flying Dutchman”, Elsa in “Lohengrin”, Elisabeth in “Don Carlos”, Amelia in “Simon Boccanegra”, Alice Ford in “Falstaff”, Valencienne in “The Merry Widow”, and Electress Marie in “The Bird Seller” by Zeller. In the 1972-73 season at Basel Theatre she sang the role of Mariane in the revival of Reinhard Kaiser’s wholly forgotten opera “Masaniello furioso”. She has also had a successful career as a concert singer.